Huntingtin Aggregates and Mitochondrial Pathology in Skeletal Muscle but not Heart of Late-Stage R6/2 Mice
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چکیده
منابع مشابه
Dietary restriction increases skeletal muscle mitochondrial respiration but not mitochondrial content in C57BL/6 mice
Dietary restriction (DR) is suggested to induce mitochondrial biogenesis, although recently this has been challenged. Here we determined the impact of 1, 9 and 18 months of 30% DR in male C57BL/6 mice on key mitochondrial factors and on mitochondrial function in skeletal muscle, relative to age-matched ad libitum (AL) controls. We examined proteins and mRNAs associated with mitochondrial biogen...
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Mitochondrial dysfunction is often observed in aging skeletal muscle and is implicated in age-related declines in physical function. Early evidence suggests that dietary omega-3 polyunsaturated fatty acids (n-3 PUFAs) improve mitochondrial function. Here, we show that 10 weeks of dietary eicosapentaenoic acid (EPA) supplementation partially attenuated the age-related decline in mitochondrial fu...
متن کاملHeart failure affects mitochondrial but not myofibrillar intrinsic properties of skeletal muscle.
BACKGROUND Congestive heart failure (CHF) induces abnormalities in skeletal muscle that are thought to in part explain exercise intolerance. The aim of the present study was to determine whether these changes actually result in contractile or metabolic functional alterations and whether they are muscle type specific. METHODS AND RESULTS With a rat model of CHF (induced by aortic banding), we ...
متن کاملHeart Failure Affects Mitochondrial but Not Myofibrillar Intrinsic Properties of Skeletal Muscle
Background—Congestive heart failure (CHF) induces abnormalities in skeletal muscle that are thought to in part explain exercise intolerance. The aim of the present study was to determine whether these changes actually result in contractile or metabolic functional alterations and whether they are muscle type specific. Methods and Results—With a rat model of CHF (induced by aortic banding), we st...
متن کاملSkeletal muscle pathology in chronic heart block.
Skeletal muscle samples, mainly from the deltoid, were studied morphologically and histochemically in 35 patients with chronic heart block and from nine elderly control subject. The average age of the first group was 67-7 (range 11-94) years. Abnormalities were present in 20 cases, no difference being found between patients with idiopathic and secondary heart block. In 15 samples there was incr...
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ژورنال
عنوان ژورنال: Journal of Huntington's Disease
سال: 2019
ISSN: 1879-6397,1879-6400
DOI: 10.3233/jhd-180324